Amphotericin B- and fluconazole-resistant Candida spp., Aspergillus fumigatus, and other newly emerging pathogenic fungi are susceptible to basic antifungal peptides.

نویسندگان

  • E J Helmerhorst
  • I M Reijnders
  • W van't Hof
  • I Simoons-Smit
  • E C Veerman
  • A V Amerongen
چکیده

The present study shows that a number of basic antifungal peptides, including human salivary histatin 5, a designed histatin analog designated dhvar4, and a peptide from frog skin, PGLa, are active against amphotericin B-resistant Candida albicans, Candida krusei, and Aspergillus fumigatus strains and against a fluconazole-resistant Candida glabrata isolate.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 43 3  شماره 

صفحات  -

تاریخ انتشار 1999